Akkermansia muciniphila – multifunctional bacteria

WOSIŃSKA, Alicja, PAZIK, Dorota, ŁOPUSZYŃSKA, Inga, KOSECKA, Katarzyna, RUDZIŃSKI, Patryk, CIEŚLIK, Aleksandra, JARGIEŁO, Anna, KOSIERADZKA, Karolina, ADAMOWICZ, Dominik and STAŃCZYK, Justyna. Akkermansia muciniphila – multifunctional bacteria. Journal of Education, Health and Sport. 2023;21(1):78-91. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.21.01.009

https://apcz.umk.pl/JEHS/article/view/44833

https://zenodo.org/record/8169167

 

 

 

 

 

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 29.06.2023. Revised: 29.06.2023. Accepted: 20.07.2023. Published: 25.07.2023.

 

 

 

 

 

Akkermansia muciniphila – multifunctional bacteria

 

Alicja Wosińska

Marshal Józef Piłsudski Memorial Hospital in Płońsk, Henryka Sienkiewicza 7, 09-100 Płońsk

 https://orcid.org/0009-0000-8712-6148

Dorota Pazik

Orłowski Hospital, ul. Czerniakowska 231, 00-416 Warszawa

 https://orcid.org/0009-0008-6826-0083

Inga Łopuszyńska

The National Institute of Medicine of the Ministry of Interior and Administration, Wołoska 137, 02-507 Warszawa

 https://orcid.org/0000-0002-0002-9917

Katarzyna Kosecka

The National Institute of Medicine of the Ministry of Interior and Administration, Wołoska 137, 02-507 Warszawa

 https://orcid.org/0009-0001-8434-7030

Patryk Rudziński

Orłowski Hospital, ul. Czerniakowska 231, 00-416 Warszawa

 https://orcid.org/0000-0003-4709-2187

Aleksandra Cieślik

Praski Hospital in Warsaw, Aleja Solidarności 67, 03-401 Warszawa

 https://orcid.org/0009-0007-0272-8045

 

Anna Jargieło

Military Institute of Medicine - National Research Institute, ul. Szaserów 128, 04-141 Warszawa

 https://orcid.org/0009-0008-9300-4655

Karolina Kosieradzka

Praski Hospital, Aleja Solidarności 67, 03-401 Warszawa

 https://orcid.org/0000-0002-2446-6396

Dominik Adamowicz

University Clinical Centre of the Medical University of Warsaw, Banacha 1a, 02-097 Warszawa

 https://orcid.org/0009-0007-0386-9392

Justyna Stańczyk

National Geriatrics, Rheumatology and Rehabilitation Institute, name of prof. Eleonora Reicher in Warsaw, Spartańska 1, 02-637 Warszawa

 https://orcid.org/0000-0002-6004-4406

 

 

ABSTRACT

 

Introduction: The complex symbiotic connection between the host and the gut microbiome, which has many important functions in the organism, provides an opportunity for dysbiosis to potentially serve as a catalyst for various health disorders. Akkermancia muciniphila, a bacterium that degadates mucin, is a noteworthy element of the human gut microbiome and has captured the attention of researchers due to its correlation with numerous diseases.

 

Aim of the study: The purpose of this research was to review literature and determine the impact of Akkermansia muciniphila in selected diseases. A systematic review was conducted using PubMed database.

 

State of knowledge: Studies have shown that reduced numbers of Akkermansia muciniphila have been associated with many diseases, including obesity, type 2 diabetes, atherosclerosis, fatty liver, some neurological conditions, inflammation, and response to cancer immunotherapies. Furthermore, the administration of this bacterium has been shown to have a positive impact on reducing obesity-related parameters, improving insulin sensitivity and glucose homeostasis, mitigating inflammation, and enhancing the prognosis of immune checkpoint inhibitor treatment.

 

Conclusions: The condition and composition of the intestinal microbiome play a significant role in the development and progression of numerous diseases. Akkermansia muciniphila, as demonstrated in various studies, is an example of a bacterium associated with beneficial effects in multiple diseases. It is regarded as a promising candidate for probiotic use.

 

Keywords: gut microbiota; Akkermansia muciniphila; probiotic; dysbiosis; metabolic diseases.