Unscrewing DHT-Blocking Properties of Allium Cepa Extract: Virtual Screening of active Compounds against 5-Alpha Reductase and Evaluation of Adme/T Properties of Compounds

Androgenetic alopecia (AGA) is a condition
that affects both men and women with a genetic
predisposition, causing a non-scarring reduction in the
size of hair follicles.The underlying cause can be
attributed to the enzyme 5-alpha-reductase, which
converts testosterone into dihydrotestosterone (DHT).
DHT, a potent androgen formed from testosterone by
the action of 5-alpha-reductase enzymes, attaches to
androgen receptors in susceptible hair follicles, leading
to a decrease in size and eventually halting hair growth.
The accumulation of DHT in hair follicles results in hair
loss. The primary therapeutic approach for treating
AGA revolves around inhibiting 5-alpha-reductase.
Recently, there has been growing interest in the use of
Allium cepa (onion) extract as a natural remedy for
AGA. This study focuses on conducting in silico and
ADME/T analyses of the active compounds found in
onion extract to assess and visualize their interaction
with 5-alpha-reductase protein.