Current views on pathogenesis of rosacea

BARCZAK, Iga, BONDOS, Borys, KOCHAN, Robert, BARCZUK, Patryk, BARA, Sebastian, DZIĘGIELEWSKI, Jędrzej, BĄCZEK, Kacper, BARĆ, Jan, GAŁAJDA, Elżbieta and ANTONIK, Jacek. Current views on pathogenesis of rosacea. Journal of Education, Health and Sport. 2023;18(1):109-122. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.18.01.011

https://apcz.umk.pl/JEHS/article/view/44150

https://zenodo.org/record/8138043

 

 

 

 

 

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 22.05.2023. Revised: 24.06.2023. Accepted: 18.07.2023. Published: 18.07.2023.

 

 

 

 

 

CURRENT VIEWS ON THE PATHOGENESIS OF ROSACEA

 

 

Iga Barczak¹, Borys Bondos², Robert Kochan³, Patryk Barczuk⁴, Sebastian Bara⁵, Jędrzej Dzięgielewski⁶, Kacper Bączek⁷, Jan Barć⁸, Elżbieta Gałajda⁹, Jacek Antonik¹⁰

1) Student, Wydział Lekarski, Uniwersytet Medyczny w Lublinie

https://orcid.org/0009-0009-5882-2019 | iga5412@gmail.com

2) Student, Wydział Lekarski, Uniwersytet Medyczny w Lublinie

https://orcid.org/0009-0005-7971-4691 | borysb97@gmail.com

3) Student, Wydział Lekarski, Uniwersytet Medyczny w Lublinie 

https://orcid.org/0009-0002-9796-9231 | robkochan2211@gmail.com 

4) Student, Wydział Lekarski, Uniwersytet Medyczny w Lublinie

https://orcid.org/0009-0004-2271-8782 | patryk.barczuk11235@gmail.com

5) Student, Wydział Lekarski, Uniwersytet Medyczny w Lublinie

https://orcid.org/0009-0009-7022-1312| granellosz@gmail.com

6) Student, Wydział Lekarski, Uniwersytet Medyczny w Lublinie 

https://orcid.org/0009-0001-9475-1766 | dziegielewskijedrzej@gmail.com  

7) Student, Wydział Lekarski, Uniwersytet Medyczny w Lublinie

https://orcid.org/0000-0003-2860-8360?lang=en kacperz0909@gmail.com 

 

8) Student, Wydział Lekarski, Uniwersytet Medyczny w Lublinie

https://orcid.org/0009-0004-8087-6252 | jan8876@gmail.com

9) Student, Wydział Lekarski, Uniwersytet Medyczny w Lublinie 

https://orcid.org/0009-0008-6465-1490 | elagalajda@gmail.com

10) Student, Wydział Lekarski, Uniwersytet Medyczny w Lublinie

https://orcid.org/0009-0003-9583-1631 | jacek.antonik@o2.pl

 

 

ABSTRACT

Rosacea is a chronic inflammatory disease that usually affects the central part of the face. The primary symptoms include facial flushing, persistent erythema, telangiectasia,  inflammatory pustules and papules. Based on groups of these symptoms, four basic rosacea subtypes have been defined: erythematotelangiectatic, papulopustular, ocular, phymatous; and one variant, granulomatous rosacea. Although the pathophysiology of this disorder is not fully known, many components such as immune and neurovascular dysregulation, oxidative stress, genetic background, gut microbiome, skin microbiome as well as external aspects are thought to play a role. In this article, we present the main factors that are speculated to be involved in the pathogenesis of rosacea.

Methods and materials: We reviewed the literature available on PubMed and Google Scholar using the words "rosacea”, „rosacea pathogenesis”, „demodex”, „reactive oxygen forms”, „rosacea microbiome”.

Summary

Rosacea is a chronic dermatosis whose etiology, despite many studies, is not fully understood. Currently, an abnormal inflammatory reaction caused by excessive stimulation of TLR-2 receptors is suspected as the main factor in the pathomechanism of the disease. Vascular disorders, transmission disorders, genetic factors, skin and intestinal dysbiosis also participate in the pathogenesis of rosacea. It is assumed that exogenous factors such as diet and exposure to UV radiation also play a role in the development of the disease.

 

 

Keywords: rosacea, rosacea pathogenesis, demodex, reactive oxygen species, rosacea microbiome