Published August 9, 2022 | Version v1
Journal article Open

Direct access to unnatural cyclobutane a-amino acids through visible light catalyzed [2+2]-cycloaddition

Authors/Creators

  • 1. Westfälische-Wilhelms University Münster
  • 2. University of Siena

Description

The first selective, photocatalyzed [2+2]-cycloaddition of dehydroamino acids with styrenetype olefins is presented. This simple, mild, and scalable approach relies on the use of the triplet energy transfer catalyst [Ir(dFCF3ppy2)dtbpy]PF6 under visible light irradiation and provides fast access to value-added substituted strained cyclobutane α-amino acid derivatives

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2+2_ACS O&I Chem Au.pdf

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Additional details

Funding

European Commission
FRICatANIONS - Frontiers in Catalytic Anion-Binding Chemistry 724695