SYNTHESIS OF PHOSPHONIC ACIDS OF POLYFUNCTIONAL PYRIDOPYRIMIDINES

In the article synthesized 2,3-trimethylene-3,4-dihydropyrido[2,3-d] pyrimidin-4-one from 2-Aminonicotinic acid and pyrrolidone-2 in the presence different agents, such as PCl₅, POCl₃. Its reduction reaction with NaBH₄ carrying out. Obtained 2,3-trimethylene-1,2,3,4-tetrahydropyrido[2,3-d] pyrimidin-4-one – this three-component coupling of a carbonyl, an amine and a hydrophosphoryl compoud leads to α-aminophosphonates, phosphorous acid-formaldehyde; aldehydes in three component system; minomethylphosphonic acid synthesis based on kabachnik-filds reaction. 2,3-trimethylene-3,4-dihydropyrido[2,3-d] pyrimidin-4-one 35% da product obtained. The reason of low reaction yield was studied. Structures were confirmed using IR and 1H NMR spectroscopies. Obtained product reduced using NaBH₄ and 2,3-trimethylene-1,2,3,4-tetrahydropyrido[2,3-d] pyrimidin-4-one synthesis was carried out with high yield. 2,3-trimethylene-1,2,3,4-tetrahydropyrido[2,3-d] pyrimidin-4-one and respective aminophosphonic acids were synthesized in three component system with high yield.