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Published July 17, 2023 | Version v1
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Mechanical transmission of Dengue Virus by Aedes aegypti may influence disease transmission dynamics during outbreaks data

Authors/Creators

  • 1. University of California, San Diego
  • 2. Nagoya University
  • 3. National Taiwan University
  • 4. National Health Research Institutes
  • 5. National Tsing Hua University
  • 6. National Chiao Tung University
  • 7. National Chung Hsing University
  • 8. Kaohsiung City Government*
  • 9. University of California, Berkeley

Description

Summary

Background: Dengue virus outbreaks are increasing in number and severity worldwide. Viral transmission is assumed to require a minimum time period of viral replication within the mosquito midgut. It is unknown if alternative transmission periods not requiring replication are possible.

Methods: We used a mouse model of dengue virus transmission to investigate the potential of mechanical transmission of dengue virus. We investigated minimal viral titres necessary for development of symptoms in bitten mice and used resulting parameters to inform a new model of dengue virus transmission within a susceptible population.

Findings: Naïve mice bitten by mosquitoes immediately after they took partial blood meals from dengue infected mice showed symptoms of dengue virus, followed by mortality. Incorporation of mechanical transmission into mathematical models of dengue virus transmission suggests that this supplemental transmission route could result in larger outbreaks which peak sooner.

Interpretation: The potential of dengue transmission routes independent of midgut viral replication has implications for vector control strategies that target mosquito lifespan and suggest the possibility of similar mechanical transmission routes in other disease-carrying mosquitoes.

Notes

Funding provided by: National Health Research Institutes
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100004737
Award Number: 04D2-MMMOST02

Funding provided by: Ministry of Science and Technology
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100003711
Award Number: MOST104-2321-B-400-016

Funding provided by: National Institutes of Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000002
Award Number: 1R01AI143698-01A1

Funding provided by: Ministry of Science and Technology
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100003711
Award Number: MOST104-2321-B-400-016

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Additional details

Related works

Is cited by
10.1101/2023.03.07.531453 (DOI)