A Curated Gene and Biological System Annotation of Adverse Outcome Pathways Related to Human Health
Creators
- 1. Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
- 2. Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Tampere Institute of Advanced Studies, Tampere University, Tampere, Finland
- 3. Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Institute of Biotechnology, HiLife, University of Helsinki, Helsinki, Finland
Description
Adverse Outcome Pathways (AOPs) are multi-scale models of biological mechanisms connecting molecular initiating events to adverse outcomes through measurable key events. AOPs can guide the use and development of new approach methodologies (NAMs) aimed at reducing animal experimentation in chemical safety assessment. Here, we present a comprehensive molecular annotation of AOPs relevant to human health to embed the AOP framework into molecular data interpretation, which supports the development and application of novel AOP-based approaches in biomedical research.
Please cite the following publication alongside this Zenodo entry when using the data:
Saarimäki, L.A., Fratello, M., Pavel, A. et al. A curated gene and biological system annotation of adverse outcome pathways related to human health. Sci Data 10, 409 (2023). https://doi.org/10.1038/s41597-023-02321-w
Files
Genes_to_KEs.txt
Files
(14.7 MB)
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md5:299713d4cbff6c640a09bd6de8e62a0c
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md5:8d4383a669d73876e5a668ed939f0338
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Additional details
Funding
- European Commission
- NanoSolveIT – Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology (NanoSolveIT) 814572
- Research Council of Finland
- UNICAST NANO: A Unified Chemical Space For Next Generation Predictive Nanotoxicology and Nanopharmacology 322761
- European Commission
- ARCHIMEDES – dAta-dRiven integrated approaches to CHemIcal safety assessMEnt and Drug dEvelopment 101043848