Published April 18, 2023 | Version v1
Peer review Open

Molecular mimicry and cancer vaccine development

Creators

  • 1. Istituto Nazionale Tumori - IRCCS "Pascale"

Description

Molecular mimicry: homology in the TCR facing residues and molecular interaction. The MAGE-A1278-286 peptide and the homologous peptide derived from Faecalibacterium prausnitzii (WP_158387495.1) are shown bound to the HLA-A*02:01 molecule. The identical residues K1, E4, Y5, I7 are presented to the TCR αβ chains with the same conformation (A – D). The contact areas in red between the two peptides and the TCR αβ chains are identical (E - H). The areas of contact between the HLA molecule and the TCR αβ chains are identical (yellow and dark blue areas) (I, J).

Files

Diapositiva1.PNG

Files (2.5 MB)

Name Size Download all
md5:8df76c7b3677bc8fe3ae94385fa83955
593.0 kB Preview Download
md5:91f52ab8c7a43b7d35fb428754fbaa9a
1.2 MB Preview Download
md5:76b4e163af5fa0563b8924d26b206404
698.4 kB Preview Download

Additional details

Related works

References
Journal article: 3404-9932 (ISSN)
Journal article: 35836198 (PMID)