Published January 12, 2023 | Version v2
Journal article Open

GWAS Summary Statistics from a Global Meta-Analysis of Aortic Stenosis

Creators

  • 1. Division of Experimental Medicine, McGill University and Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, Canada
  • 2. Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France
  • 3. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States
  • 4. Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, United States
  • 5. deCODE genetics/Amgen Inc., Reykjavik, Iceland
  • 6. McGill University and Genome Quebec Innovation Centre, Montreal, Canada
  • 7. Department of Cardiology, Clinical Sciences, Lund University, Skåne University Hospital, Lund, and The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
  • 8. MRC Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
  • 9. Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
  • 10. Division of Experimental Medicine, Department of Human Genetics, McGill University, and Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, Canada
  • 11. Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States
  • 12. Department of Cardiology, Assistance Publique - Hôpitaux de Paris, Bichat Hospital, Paris, France and Division of Cardiology, University of Ottawa Heart Institute, Ottawa (ON), Canada
  • 13. Division of Research, Kaiser Permanente of Northern California, Oakland, United States
  • 14. Department of Public Health Sciences, University of California Davis, Davis, United States
  • 15. Univ. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, UMR1283-8199 EGID, Lille, France and Department of Metabolism, Imperial College London, London, United Kingdom
  • 16. Internal Medicine and Emergency Services, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
  • 17. deCODE genetics/Amgen Inc., Internal Medicine and Emergency Services, Landspitali – The National University Hospital of Iceland, and School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  • 18. deCODE genetics/Amgen Inc. and School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  • 19. deCODE genetics/Amgen Inc. and School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
  • 20. Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet and Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen, Denmark
  • 21. Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark
  • 22. Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
  • 23. Department of Clinical Immunology, Zealand University Hospital, Naestved, Denmark
  • 24. Department of Clinical Immunology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
  • 25. Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
  • 26. Regeneron Genetics Center, New York, United States
  • 27. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Boston, United States
  • 28. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, United States
  • 29. Faculty of Medicine, University of Iceland, Reykjavík, Iceland
  • 30. Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, United States
  • 31. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, USA
  • 32. McGill University and Genome Quebec Innovation Centre and Department of Human Genetics, McGill University, Montreal, Canada
  • 33. Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
  • 34. Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
  • 35. Department of Cardiology, Clinical Sciences, Lund University, Skåne University Hospital, Wallenberg Center for Molecular Medicine, Lund University Diabetes Center, Lund, and The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
  • 36. Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States
  • 37. Division of Experimental Medicine, McGill University and Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute and Department of Human Genetics, McGill University, Montreal, Canada

Description

GWAS Summary Statistics for a Global Meta-Analysis of Aortic Stenosis in the TARGET Consortium

10.5281/zenodo.7630002

This dataset contains the genome-wide association summary statistics for a Global Meta-Analysis of Aortic Stenosis. For the analysis description and included cohorts, please see Chen et al., the European Heart Journal (2023).

The data are provided on an "AS-IS" basis, without warranty of any type, expressed or implied, including but not limited to any warranty as to their performance, merchantability, or fitness for any particular purpose. If investigators use these data, any and all consequences are entirely their responsibility. By downloading and using these data, you agree that you will cite the appropriate publication in any communications or publications arising directly or indirectly from these data. 

When using this data, please cite the paper and this repository:

  1. Chen et al., GWAS Summary Statistics for a Global Meta-Analysis of Aortic Stenosis, the European Heart Journal (2023).

  2. Zenodo. 10.5281/zenodo.7630002

Column headers:

CHR: Chromosome code. Not present with 'no-map' modifier.

BP: Base-pair coordinate. Not present with 'no-map' modifier.

SNP: Variant identifier

A1: Effect Allele

A2: Other Allele

N_cohort: Number of valid studies for variant

P: Fixed-effects meta-analysis p-value

P.R.: Random-effects meta-analysis p-value

OR: Fixed-effects BETA/OR estimate

OR.R.:  Random-effects BETA/OR estimate

Q: p-value for Cochran's Q statistic

I: I2 heterogeneity index (0-100 scale)

N_ind: Number of individuals

Fundings:

Fundings for this study were obtained from the following (listed in alphabetical order):

  • ALFEDIAM

  • Ardix Medical 

  • Assistance Publique - Hôpitaux de Paris 

  • Association Diabète Risque Vasculaire

  • Bayer Diagnostics

  • Becton Dickinson

  • British Heart Foundation

  • British Heart Foundation Oxford Centre

  • Canadian Institutes for Health Research

  • Capital Regions Research Council

  • Cardionics, Merck Santé, Novo Nordisk

  • CNAMTS, Lilly, Novartis Pharma

  • Cohortes Santé TGIR

  • County Council of Västerbotten

  • Crafoord Foundation

  • Ellison Medical Foundation

  • European Research Council

  • Fédération Française de Cardiologie

  • Fédération Française de Cardiologie, a Fondation Coeur et Recherche

  • Fonds de Recherche du Québec - Santé.

  • French Regional Council of Pays-de-la-Loire (VaCaRMe program)

  • Heart and Stroke Foundation of Canada

  • Heart Foundation of Northern Sweden.

  • Kaiser Permanente

  • Knut and Alice Wallenberg foundation to the Wallenberg Center

  • La Fondation de France

  • Medical Research Council and the University of Oxford

  • National Center for Advancing Translational Sciences (CTSI)

  • National Heart, Lung, and Blood Institute (NHLBI)

  • National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC)

  • National Institutes of Health

  • Novo Nordisk Foundation

  • ONIVINS

  • Robert Wood Johnson Foundation

  • Sanofi-Aventis; by INSERM (Réseaux en Santé Publique, Interactions entre les déterminants de la santé)

  • Skåne University Hospital

  • Société francophone du diabète

  • Swedish Foundation for Strategic Research

  • Swedish Heart–Lung Foundation

  • Swedish National Health Service

  • Swedish Research Council

  • The Innovation Fund Denmark

  • Umeå University

  • U.S. Department of Veteran Affairs

  • Vanderbilt University Medical Center’s institutional funding

  • Wayne and Gladys Valley Foundation

 

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