Published April 14, 2023 | Version v1
Dataset Open

Genome assemblies: Horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae ST23/KL57 to Serratia marcescens

Authors/Creators

  • 1. Department of Clinical Microbiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
  • 2. Department of Thoracic Anaesthesiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
  • 3. Center for Genomic Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
  • 4. Bacteria, parasites and fungi, Statens Serum Institut, Copenhagen, Denmark
  • 5. Department Molecular Bacteriology, Helmholtz Centre for Infection Research, Braunschweig, Germany
  • 6. Department of Infectious diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark

Description

Hypervirulent Klebsiella pneumonia isolates express a range of virulence factors, often encoded on virulence plasmids. Occasionally these hypervirulent lineages acquire antimicrobial resistance genes rendering them multidrug-resistant. We describe the nosocomial transmission of a hypervirulent K. pneumoniae ST23/KL57 isolate carrying an NDM-1 and OXA-48 beta-lactamase among COVID-19 patients in a Danish university hospital. Furthermore, we characterize the plasmid structure and describe a within-patient horizontal transfer of a plasmid carrying a blaOXA-48 gene from K. pneumoniae ST23/KL57 to a Serratia marcescens isolate.

Files

Files (16.4 MB)

Name Size Download all
md5:696b5aa993577569a3152f75ffb09219
5.4 MB Download
md5:a8cd589e5ccf0faa69e8d22a415c4453
5.7 MB Download
md5:0251bb61880a1e13914e1bb4fd4a33ed
5.3 MB Download