DESIGN AND IN-VITRO EVALUATION OF FAST DISINTEGRATING TABLETS OF AN ANTIHYPERTENSIVE DRUG

Aim:The aim of the work was an attempt to make the formulation of fast disintegrating tablets of Diltiazem HCl by direct compression method with the aid of superdisintegrants addition.

Method: Fast disintegrating tablets of Diltiazem HCl were prepared by direct compression method. Nine formulations were developed by using three different superdisintegrants in varying concentrations in such a way that total weight of the tablet remains same. The drug-polymer incompatibility was ruled out by FTIR studies. All the formulated tablets were subjected for pre and post-compression evaluation parameters. A comparison of in vitro drug release of optimized formulation (DF9) was compared with marketed product (Dilzem).

Result: From the FTIR studies, the drug-polymers compatibilities were confirmed. All the formulated tablets were showing satisfactory results which comply with the official limits.

Conclusion: Among the nine formulations, the formulation containing 4.5% crospovidone (DF9) showed highest drug release of 95.72% as compared to other formulations. A comparison of in vitro drug release was made with marketed product of Diltiazem HCl (Dilzem) which shows 92.53% drug release in 1 hour. From this study we can make the conclusion that the formulated tablets of Diltiazem HCl containing crospovidone are better and effective than conventional tablets to meet patient compliance along with fast relief from hypertention and angina.

Keywords: Formulation; FTIR studies; In vitro drug release; Diltiazem HCl; Fast disintegrating tablets; Superdisintegrant etc.