Proteomic and metabolomic analysis of COVID-19 nasal swabs
Description
The epithelial barrier's primary role is to protect against entry of foreign and pathogenic elements. Global and targeted approaches were applied to nasal swabs from healthy and COVID-19-confirmed cases within 24 hours post-positive-confirmation and at 3 weeks post-infection to observe changes in proteome and metabolome.
We found that the tryptophan/kynurenine metabolism pathway is a pinch-point regulator of canonical and non-canonical transcription activation, macrophage release of cytokines and significant changes in the immune and metabolic status with increasing severity and disease course.
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Funding provided by: Millenium Pharmaceutical Research Grant*
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Award Number: NA
Funding provided by: Mark Wainwright Analytical Centre, UNSW*
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Additional details
Related works
- Is cited by
- 10.3390/ijms232314776 (DOI)