Accurate and Efficient Estimation of Local Heritability using Summary Statistics and LD Matrix -- Demo datasets for the HEELS tutorials
Creators
- 1. Harvard T.H. Chan School of Public Health
- 2. MIT Sloan School of Management
Description
We introduced a new estimator for local heritability, "HEELS", which attains comparable statistical efficiency as the REML estimator (such as those produced by GCTA and BOLT-REML) but only requires summary-level statistics – Z-scores from marginal association tests and the empirical LD. Our method has been implemented into an open-source Python-based command line tool.
The datasets released here can be downloaded to test the two main functions of our software package: 1) estimating local heritability; 2) computing the low-dimensional representation of the LD matrix. They are meant to accompany the HEELS tutorials we have posted onto the wiki pages of our github repository: https://github.com/huilisabrina/HEELS/wiki.
Notes
Files
ukb_30k_simul_pheno.txt
Files
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