Data for: The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice
Creators
- 1. Institut de Biologie de l'École Normale Supérieure
Description
Fear extinction is a form of inhibitory learning that suppresses the expression of aversive memories and plays a key role in the recovery of anxiety and trauma-related disorders. Here, using male mice, we identify a cerebello-thalamo-cortical pathway regulating fear extinction. The cerebellar fastigial nucleus (FN) projects to the lateral subregion of the mediodorsal thalamic nucleus (MD), which is reciprocally connected with the dorsomedial prefrontal cortex (dmPFC). The inhibition of FN inputs to MD in male mice impairs fear extinction in animals with high fear responses and increases the bursting of MD neurons, a firing pattern known to prevent extinction learning. Indeed, this MD bursting is followed by high levels of the dmPFC 4 Hz oscillations causally associated with fear responses during fear extinction, and the inhibition of FN-MD neurons increases the coherence of MD bursts and oscillations with dmPFC 4 Hz oscillations. Overall, these findings reveal a regulation of fear-related thalamo-cortical dynamics by the cerebellum and its contribution to fear extinction.
Notes
Funding provided by: Fondation pour la Recherche Médicale
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002915
Award Number: DPP20151033983
Funding provided by: Fondation pour la Recherche Médicale
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002915
Award Number: EQU202103012770
Funding provided by: Agence Nationale de la Recherche
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001665
Award Number: ANR-21-CE37-0025
Funding provided by: Agence Nationale de la Recherche
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001665
Award Number: ANR-17-CE37-0009
Funding provided by: Agence Nationale de la Recherche
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001665
Award Number: ANR-17-CE16-0019
Funding provided by: Agence Nationale de la Recherche
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001665
Award Number: ANR-21-CE16-0017
Funding provided by: Agence Nationale de la Recherche
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001665
Award Number: ANR-10-INBS-04
Funding provided by: Agence Nationale de la Recherche
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001665
Award Number: ANR-10-LABX-54
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Additional details
Related works
- Is source of
- 10.5061/dryad.9kd51c5ng (DOI)