Chronic pruritus in atopic dermatitis

Atopic dermatitis (AD) is an inflammatory skin disease which characterized by chronic recidive skin rash and accompanied by complaints of pruritus. Chronic pruritus is reported to occur in 87-100% of AD patients and often affecting patient's quality of life. Management of chronic pruritus with antihistamines in AD is often ineffective, thus different pruritogens are considered to undergone the histamine-independent itch pathway.