ANTI-HYPERGLYCEMIC AND HEPATOPROTECTIVE PROPERTIES OF COMBINED AQUEOUS LEAF EXTRACT OF Vernonia amygdalina AND Moringa oleifera IN EXPERIMENTALLY INDUCED DIABETIC RAT MODEL

Abstract: This study was carried out to investigate the anti-hyperglycemic and hepato-protective properties of combined leaf extracts of Vernonia amygdalina and Moringa oleifera in alloxan-induced diabetic Wistar rats. The study design involved 25 rats weighing 140 to 2100g which were randomly divided into 5 groups of 5 rats each. Group 1 received distilled water and feed; group 2 received no treatment; group 3 received 4% extract combination of V. amygdalina and M. oleifera; group 4 received 8% extract combination of V. amygdalina and M. oleifera and group 5 received 16% extract combination of V. amygdalina and M. oleifera. After 14 days of treatment, the animals were anaesthetized and sacrificed to obtain blood by cardiac puncture. Serum was collected and assayed for alanine aminotransaminase (ALT), aspartate aminotransferases (AST) and alkaline phosphatase (ALP) while the blood glucose levels were determined using hand-held glucometer. The results showed a significant (p<0.05) reduction in blood glucose levels of treatment groups with combined extracts of V. amygdalina and M. oleifera when compared with normal control and negative control groups. Also, the ALT, AST and ALP levels of the treatment groups decreased significantly (p<0.05) when compared with the normal control and negative control group. This reduction in blood glucose levels and liver enzyme markers can be attributed to presence of bioactive compounds in both plants working synergistically. Hence, V. amygdalina and M. oleifera combination may be more potent in management of diabetes.

Keywords: Diabetes, Vernonia amygdalina, Moringa oleifera, Aanti-hyperglycemic, hepatoprotective, Liver enzymes.

Title: ANTI-HYPERGLYCEMIC AND HEPATOPROTECTIVE PROPERTIES OF COMBINED AQUEOUS LEAF EXTRACT OF Vernonia amygdalina AND Moringa oleifera IN EXPERIMENTALLY INDUCED DIABETIC RAT MODEL

Author: Omeodu SI, Uahomo PO

International Journal of Recent Research in Life Sciences (IJRRLS)

ISSN 2349-7823

Vol. 10, Issue 1, January 2023 - March 2023

Page No: 1-7

Paper Publications

Website: www.paperpublications.org

Published Date: 01-January-2023

DOI: https://doi.org/10.5281/zenodo.7496485

Paper Download Link (Source)

https://www.paperpublications.org/upload/book/ANTI-HYPERGLYCEMIC%20AND%20HEPATOPROTECTIVE-01012023-2.pdf