Comparative Study Of The Effects Of Long-Term Used Representatives Of Calsium Channel Antogonists From Different Chemical Groups On The Course Of Pregnancy And Prenatal Development

The main purpose of the work was the comparative study of the influence of long-term used representatives of calcium channel blockers from different chemical groups on the course of pregnancy and intrauterine development of fetus. Experiments were performed on 126 adult albino female rats reached sexual maturity, with weight of 190-220g. The animals were divided into one control and 3 experimental groups, 32 females in each group. Verapamil, nifedipine and dilitazem in 5 mg/kg doses were administered daily into abdominal area of animals in experimental groups during 21 days before pregnancy. Weights of the animals before and after birth, and weights of fetuses were measured. Number of fetuses, their physical development and possible anomalies were controlled visually. According to the results no anomalies were observed in pups and duration of pregnancy was prolonged. Weights of the animals in varapamil and dilitazem groups decreased compared with the control group rats before as well as after birth. Decreases were observed also in the fetal numbers and body weights. Statistically unreliable changes of the body weights after birth compared with the control group animals were observed for the nifedipine group females. No significant changes compared with the other group animals were observed in fetuses of nifedipine group females.