Published October 7, 2009
| Version v1
Conference paper
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Droplet Generation by means of a Two-Fluid Probe
Creators
- 1. Institute for Bioprocessing and Analytical Measurement Techniques
Description
This paper presents a simulation of the operation new type of droplet generation probe. This probe, consisting of two concentrically-arranged tubings, is immersed in a beaker of cell medium so that oil is pumped through the outer tubing at a pumping speed less than fluid is drawn into the inner tubing. In this way, droplets of cell medium are entrained into the outlet tubing forming a segmented flow of homogeneously mixed droplets. The simulation allows the sizing and spacing of the droplets to be ascertained.
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References
- J. R. Burns and C. Ramshaw, The intensification of rapid reactions in multiphase systems using slug flow in capillaries, Lab on a Chip, 1, 10-15 (2001)
- T. Thorsen, R. W. Roberts, F. H. Arnold and S. R. Quake, Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device, Physical Review Letters, 86, 4163-4166 (2001)
- T. Nisisako, T. Torii and T. Higuchi, Droplet formation in a microchannel network, Lab on a Chip, 2, 24-26 (2002)
- A. Grodrian, J. Metze, T. Henkel, M. Roth and J. M. Köhler, Segmented flow generation by chip reactors for highly parallelized cell cultivation, Proc. SPIE, 4937, 174-181 (2002)
- K. Martin, T. Henkel, V. Baier, A. Grodrian, T. Schön, M. Roth, J. Köhler and J. Metze, Generation of larger numbers of separated microbial populations by cultivation in segmented-flow microdevices, Lab on a Chip, 3, 202-207 (2003)
- A. Grodrian, J. Metze, T. Henkel, K. Martin, M. Roth and J. M. Köhler, Segmented flow generation by chip reactors for highly parallelized cell cultivation, Biosensors and Bioelectronics, 19, 1421-1428 (2004)
- J. Köhler, T. Henkel, A. Grodrian, T. Kirner, M. Roth, K. Martin and J. Metze, Digital reaction technology by micro segmented flow— components, concepts and applications, Chemical Engineering Journal, 101, 201-216 (2004)
- T. Henkel, T. Bermig, M. Kielpinski, A. Grodrian, J. Metze and J. Köhler, Chip modules for generation and manipulation of fluid segments for micro serial flow processes, Chemical Engineering Journal, 101, 439-445 (2004)
- J. Liow, Numerical simulation of drop formation in a T-shaped microchannel, 15th Australasian Fluid Mechanics Conference, (2004)
- S. van der Graaf, T. Nisisako, C. G. P. H. Schroen, R. G. M. van der Sman and R. M. Boom, Lattice Boltzmann Simulations of Droplet Formation in a T-Shaped Microchannel, Langmuir, 22, 4144-4152 (2006)
- K. Lemke, G. Gastrock, A. Grodrian, R. Römer, M. Quade, M., D. Roscher, Anordnung und Verfahren zum Erzeugen, Manipulieren und Analysieren von Kompartimenten. Patent DE 10 2008 039 117.4 (2008)
- J. Schemberg, A. Grodrian, R. Römer, G. Gastrock and K. Lemke, Online optical detection of food contaminants in microdroplets, Engineering in Life Sciences, in press (2009) doi:10.1002/elsc.200800127