What's state-of-the-art for NTS in the reversed phase LC-HRMS analytical toolbox?

This presentation given on the NORMAN NTS workshop on analytical techniques  and implementation in Odense, Denmark, covers the question of the state-of-the-art of reversed phase chromatography in nont-target screening. It includes an overview on the current used chromatography systems, on the influence of modifiers and injection volumes on the quality of peak shapes, and finally discusses recent retention time prediction and retention time indices approaches.