oncoEnrichR use cases
Creators
- 1. Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Norway
- 2. ELIXIR Norway, Department of Informatics, University of Oslo, Norway
- 3. Early Computational Oncology, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK
- 4. Centre for Bioinformatics, Department of Informatics, University of Oslo, Norway
Description
Two use cases demonstrating the functionality of oncoEnrichR for gene list interpretation and hit prioritization.
### Use case analyses - oncoEnrichR
This Zenodo repository hosts two use case output reports from
[oncoEnrichR](https://github.com/sigven/oncoEnrichR), a dedicated tool for gene
set interpretation in cancer.
Directory structure:
* __`reports`__ - holds pre-computed HTML reports and Excel workbooks for
two use cases:
1. FGFR1 network (protein proximity screen)
- `fgfr1_network_oncoEnrichR.v1.3.2.html`
- `fgfr1_network_oncoEnrichR.v1.3.2.xlsx`
2. EGFR drug resistance drivers (CRISPR screen)
- `egfr_drug_resistance_oncoEnrichR.v1.3.2.html`
- `egfr_drug_resistance_oncoEnrichR.v1.3.2.xlsx`
* __`input`__ - holds input data for the two use cases
1. fgfr1_network_input.tsv
2. egfr_drug_resistance_input.tsv
* __`docker`__ - holds input and code for re-running use case analyses through
a Docker container
__Docker instructions__
- [Install Docker](https://docs.docker.com/get-docker/) on your local computer/client (OS X/Linux)
- Download the `input` and `output` directory of the `docker` directory to your local computer/client
- Pull the Docker image with the following Docker command on the command-line:
* `docker pull sigven/oeusecase:latest`
- Run the use case analyses with the following Docker command:
* `docker run --rm -ti -v <LOCAL_DIRECTORY>/input:/input -v /LOCAL_DIRECTORY/output:/output sigven/oeusecase:latest`
- _NOTE_: replace `LOCAL_DIRECTORY` with the full path on your local computer where you have downloaded the `input` and `output` folders
* The above command will generate HTML reports and Excel workbooks for the two use cases in the `output` directory
Files
oncoenrichr_use_cases.zip
Files
(29.8 MB)
Name | Size | Download all |
---|---|---|
md5:aa037b458ede2b34138fe00040e9cb89
|
29.8 MB | Preview Download |