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Published October 10, 2022 | Version v1.4
Dataset Open

oncoEnrichR use cases

  • 1. Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Norway
  • 2. ELIXIR Norway, Department of Informatics, University of Oslo, Norway
  • 3. Early Computational Oncology, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK
  • 4. Centre for Bioinformatics, Department of Informatics, University of Oslo, Norway

Description

Two use cases demonstrating the functionality of oncoEnrichR for gene list interpretation and hit prioritization.

### Use case analyses - oncoEnrichR

This Zenodo repository hosts two use case output reports from
[oncoEnrichR](https://github.com/sigven/oncoEnrichR), a dedicated tool for gene
set interpretation in cancer.

Directory structure:

* __`reports`__ - holds pre-computed HTML reports and Excel workbooks for
  two use cases:

  1. FGFR1 network (protein proximity screen)
      - `fgfr1_network_oncoEnrichR.v1.3.2.html`
      - `fgfr1_network_oncoEnrichR.v1.3.2.xlsx`
  2. EGFR drug resistance drivers (CRISPR screen)
      - `egfr_drug_resistance_oncoEnrichR.v1.3.2.html`
      - `egfr_drug_resistance_oncoEnrichR.v1.3.2.xlsx`

* __`input`__ - holds input data for the two use cases
  1. fgfr1_network_input.tsv
  2. egfr_drug_resistance_input.tsv

* __`docker`__ - holds input and code for re-running use case analyses through
  a Docker container

  __Docker instructions__

  - [Install Docker](https://docs.docker.com/get-docker/) on your local computer/client (OS X/Linux)
  - Download the `input` and `output` directory of the `docker` directory to your local computer/client
  - Pull the Docker image with the following Docker command on the command-line:
    * `docker pull sigven/oeusecase:latest`
  - Run the use case analyses with the following Docker command:
    * `docker run --rm -ti -v <LOCAL_DIRECTORY>/input:/input -v /LOCAL_DIRECTORY/output:/output sigven/oeusecase:latest`
      - _NOTE_: replace `LOCAL_DIRECTORY` with the full path on your local computer where you have downloaded the `input` and `output` folders
    * The above command will generate HTML reports and Excel workbooks for the two use cases in the `output` directory

Files

oncoenrichr_use_cases.zip

Files (29.8 MB)

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