Dynamic Covalent Michael Acceptors to Penetrate Cells: Thiol-Mediated Uptake with Tetrel-Centered Exchange Cascades, Assisted by Halogen-Bonding Switche

Original data

1.      Synthesis and Characterization

Compounds 7, 9, 10, 11, 13, 14, 16, 33, 34, 36

• Lab Book Page; ¹H and ¹³C NMR; IR; HRMS

Compound 10 Stability Test

• Lab Book Page
• UV-Vis Absorption Spectra of 10 and 41 in PBS
• UV- Vis Absorption Spectra of 10 in Buffer After 72 h
• Kinetics 10 h in PBS; and in AMPSO Buffer

Compound 22

• Lab Book Page

Compounds 47, 48, 53, 55, 56

• Lab Book Pages; ¹H and ¹³C NMR; IR

2.      Automated High-Content High-Throughput Screening

• Lab Book Pages and Data

2.1.    Inhibitor Screening with OPS Reporter

2.2.    Cellular Uptake of MAC Reporters

2.3.    Inhibitor Screening with MAC and CTO Reporters

3.      Protein Uptake

3.1. Preparation and Cellular Uptake of Streptavidin Complexes

• Lab Book Page and Data