Antiacne gel producing with fruits from the Amazon

The use of natural products in cosmetics has been expanding due to the medicinal, economic and value-adding importance, and increased safety. The aim of this study was to analyze the fruit extract and Amazonian residues as potential ingredients for an antiacne dermocosmetic. Soxhlet extraction was performed with hexane and ethanol, and the dereplication of the extracts was performed by chemical tests, chromatographic and spectrometric analyzes. The extracts were evaluated for cytotoxicity, anti-inflammatory in vitro and antibacterial activity against P. acnes. In the end, the most promising extracts were mixed and incorporated into two pharmacopoeic gel formulations, composed by carboxymethylcellulose and Carbopol, which were evaluated for stability according to the criteria of the National Health Surveillance Agency and reassessed for antibacterial potential after exposure to different temperatures. It was possible to detect methylxanthines, phenolic acids, flavanoids and tannins in the extracts. In general, the extracts showed low cytotoxicity and good anti-inflammatory and antioxidant activity, differing more in antibacterial activity, where two ethanolic extracts G1E and TC3E were the most active and selected to compose the gel formulations. The carboxymethylcellulose-based formulation was discarded early in the stability tests. On the other hand, carbopol formulation not only retained its physicochemical characteristics but also its antibacterial properties even after exposure to extreme storage conditions. Thus, it was demonstrated that the studied Amazonian species, including their residues, have the potential to become active ingredients of antiacne products, making the continuity of this study interesting.