Published September 14, 2022
| Version v2
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Supplementary data for article "Reduced B-cell antigenicity of Omicron lowers host serologic response"
Authors/Creators
- 1. Blavatnik School of Computer Science, Tel Aviv University, Israel
- 2. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, USA
- 3. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, USA.
- 4. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, USA
- 5. School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel
Description
This repository contains five supplementary data files for the research article "Reduced B-cell antigenicity of Omicron lowers host serologic response". For more information, please refer to the article preprint https://doi.org/10.1101/2022.02.15.480546 and upcoming article at Cell Reports.
- Table_hCoV229E.xlsx: list of hCoV229E RBD sequences, with associated isolate and collection date identifiers, and ScanNet antigenicity score for reproducing Figure 3A. Aligned sequences and templates are also provided.
- table_artificial_variants.csv: List of artificial RBD sequences generated by an evolutionary-based sequence generative model for reproducing Figure 3B, Supplementary Figure S9H.
- MSA_RBD.fasta: Multiple Sequence Alignment of RBD sequences and sample weights used for training the sequence generative model used in Figure 3B, Supplementary Figures S3C, S9.
- table_antibody_hit_rate_RBD.csv: Empirical epitope distribution for the RBD, as determined from the Protein Data Bank and raw data for Supplementary Figure S1).
- RBD_virtual_DMS.xlsx: virtual Deep Mutational Scan performed with ScanNet and the sequence generative model shown in Supplementary Figure S3.