Ameloblastoma: Pathogenesis, Clinical and Radiological Features, Classification, and Management

Background: Ameloblastomas are benign epithelial odontogenic tumors affecting the jaws.

Objective: The main objective of this article is to review the pathogenesis, clinical and radiological features, classification, and management of ameloblastoma.

Methods: A literature review mainly of the Pubmed database was done using the keywords: “ameloblastoma pathogenesis”; “ameloblastoma classification”; “ameloblastoma history”; “clinical and radiological features of ameloblastoma”; and “management of ameloblastoma”.

Results: In 2017, ameloblastomas were classified by W.H.O into three categories: a) unicystic, b) conventional, and c) extraosseous/peripheral. Clinically, they are slow-growing, localized, aggressive neoplasms. Radologically, they mainly present as extensive, radiolucent, multilocular images, with a typical “soap bubble-like” appearance with a thinner, expanded, and eroded cortical plate. The linked non-erupted tooth is displaced and the roots of the adjacent teeth undergo clear resorption.

Conclusion: Because of their late signs and symptoms, ameloblastomas are usually identified at an advanced stage. Their management typically includes a large resection with safety margins and immediate reconstruction when possible. Regular long-term postoperative follow-ups are mandatory for optimum treatment outcome and recurrence prevention.