Published December 13, 2022 | Version 1
Journal article Open

Zebrafish (Danio rerio) larvae as a predictive model to study gentamicin-induced structural alterations of renal organs

  • 1. Department of Pharmaceutical Sciences, University of Basel
  • 2. Biomaterial Science Center, University of Basel
  • 3. Department of Biomedicine, University of Basel
  • 4. Synchrotron SOLEIL

Description

This repository contains reconstructed µCT scans acquired at the SOLEIL synchrotron facility which were analyzed in the above mentioned publication.

The first set of scans shows mouse kidney biopsies. One representative scan from the control group as well as one representative scan from the Gentamycin-treated group are available for download. Along with the reconstructed µCT images, a set of 5 segmentation masks is provided for each µCT scan. Each segmentation mask was generated manually and separates one specific glomerulus from the other tissue and background. The data is provided at the original (high) resolution, but cropped to the region of interest to minimize the memory footprint. In addition a binned version (resolution halved in each dimension using bilinear interpolation, done in ImageJ) of the entire µCT scan as well as the segmentation masks are provided.

The second set of scans shows zebrafish (Dario rerio) larvae. One representative scan from the control group as well as one representative scan from the Gentamycin-treated group are available for download. Along with the reconstructed µCT images, a segmentation mask is provided for each µCT scan. The segmentation masks were generated manually and separate the zebrafish larvae's [kidney tubule] from the rest of the tissue and background. The data is provided at the original (high) resolution, but cropped to the region of interest to minimize the memory footprint. In addition a binned version (resolution halved in each dimension using bilinear interpolation, done in ImageJ) of the entire µCT scan as well as the segmentation masks are provided.

 

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