Primary failure of eruption (PFE) - a systematic literature review

Nieścior Hubert, Sereda Dominika, Metelska Aleksandra, Metelski Jakub, Szwed Monika. Primary failure of eruption (PFE) - a systematic literature review. Journal of Education, Health and Sport. 2022;12(8):423-427. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.08.044

https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.08.044

https://zenodo.org/record/6983477

 

 

 

 

 

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

 

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

 

© The Authors 2022;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

 

Received: 01.08.2022. Revised: 07.08.2022. Accepted: 11.08.2022.

 

 

 

 

 

Primary failure of eruption (PFE) - a systematic literature review

 

Nieścior Hubert

https://orcid.org/0000-0002-4709-4396

hniescior@gmail.com

Medical University of Lublin, Aleje Racławickie 1, 20-059 Lublin

 

Sereda Dominika

https://orcid.org/0000-0003-4189-1674

dominika.sereda1902@gmail.com

Independent Public Clinical Hospital No. 4 in Lublin, Jaczewskiego 8, 20-954 Lublin

 

Metelska Aleksandra

https://orcid.org/0000-0002-3166-1296

metelskaaleksandra@gmail.com

Provincial Specialist Hospital of the name Stefan Cardinal Wyszyński, Aleja Kraśnicka 100, 20-718 Lublin

 

Metelski Jakub

https://orcid.org/0000-0002-7110-9332

jakub.metelski@o2.pl

Provincial Specialist Hospital of the name Stefan Cardinal Wyszyński, Aleja Kraśnicka 100, 20-718 Lublin

 

Szwed Monika

https://orcid.org/0000-0002-5711-2172

monika.pi3karska@gmail.com

Provincial Specialist Hospital of the name Stefan Cardinal Wyszyński, Aleja Kraśnicka 100, 20-718 Lublin

 

 

 

 

 

 

 

Absract

Introduction and purpose

Primary Failure of Eruption (PFE) is a rare disease that occurs more often in women than in men. PFE is extremely important for orthodontists because conventional treatment of patients results in ankylosis of the teeth affected by the disease. The aim of the study is to discuss the epidemiology, etiology, diagnosis and treatment of Primary Failure of Eruption.

Description of the state of knowledge

PFE is present in 0.05% to 0.6% of the population. The average incidence is at the age of 13.65, more often in women. Most often it affects the lateral teeth, and therefore it results in open lateral bites because the teeth do not reach the occlusal plane. The condition was found to be of genetic origin and inherited autosomal dominantly with a low percentage of incomplete penetration. The gene responsible for the disease is the PTH1R. The diagnosis of the disease consists in excluding other causes of eruption failure, detecting disease in which such symptoms occur, and genetic tests (NGS). Treatment of an open lateral bite cannot be carried out in a conventional manner due to the deterioration of the condition after the application of orthodontic forces. The result of the above actions is ankylosis of teeth covered by PFE. The currently proposed methods of treatment are: single or multi-site osteotomy, selective extractions with subsequent implantations, direct or indirect composite restorations, distraction osteogenesis, removable prosthetic restorations.

Summary

Properly conducted clinical examination of the patient should take into account PFE. Genetic testing (PTH1R) is important in the diagnosis of people with eruption disorders, which is crucial for achieving partially positive treatment results. Orthodontic treatment is contraindicated and patients with a PTH1R mutation should be monitored long-term until their growth is complete, which is the time when interdisciplinary treatment is initiated.

 

Key words: PFE; PTH1R; eruption failure; tooth eruption.