Published August 1, 2022
| Version v1
Journal article
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Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis
Description
We conducted a multiancestry meta-analysis of epigenome-wide blood DNA methylation and lung function. We combined study-specific association results using inverse variance weighted fixed effect models. Additional filtering steps were applied to identify genome-wide significant differential methylation signals. We identified numerous novel CpGs differentially methylated in relation to pulmonary function traits (FEV1, FVC, and FEV1/FVC).
Files
Metal_ALL_COPD_14_Multi.csv
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(277.9 MB)
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Additional details
Related works
- Cites
- Journal article: https://www.atsjournals.org/doi/10.1164/rccm.202108-1907OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed (URL)
- Journal article: https://pubmed.ncbi.nlm.nih.gov/35536696/ (URL)
References
- Lee, Mikyeong et al. (2022). Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis. Am J Respir Crit Care Med . 206(3):321-336. PMID: 35536696 DOI: 10.1164/rccm.202108-1907OC