Published August 9, 2022 | Version v2
Dataset Open

Data related to "Upper cortical layer-driven network impairment in schizophrenia" paper, by Batiuk, Tyler et al.

  • 1. EPFL, Lausanne, Switzerland
  • 2. Semmelweis University, Budapest, HU
  • 3. BRIC, Copenhagen University, Denmark
  • 4. Harvard Medical School, Boston, US
  • 5. Endocrinology Research Centre, Moscow, Russia
  • 6. Croatian Institute for Brain Research & Center of Excellence for Basic, Clinical and Translational Neuroscience, School of Medicine, University of Zagreb, Zagreb, Croatia
  • 7. Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary
  • 8. Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA
  • 9. Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA; St. Petersburg Polytechnical University, St. Petersburg, Russia
  • 10. Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
  • 11. Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary;

Description

This is Data for "Upper cortical layer-driven network impairment in schizophrenia" paper, by Batiuk, Tyler et al., 2022

This repository contains:

Supplementary Dataset Tables 1-4 (Supplementary_Dataset_Tables_1-4.xlsx). They contain DE genes and GO terms from snRNA-seq and visium analysis.

Single nuclei and Visium spatial transcriptomics sequencing data (snRNA-seq_and_spatial_transcriptomics.zip) containing raw count matrices of snRNA-seq samples; Conos object with aligned snRNA-seq samples; snRNA-seq single nuclei cell subtype annotations; raw count matrices of Visium spatial transcriptomics samples; Visium spatial transcriptomics manual histological cortical layer annotations; and 10x Genomics spaceranger count pipeline output for Visium spatial transcriptomics data.

Histological images of H&E stained Visium spatial transcriptomics samples mounted on visium slide capture area (visium_sample_images.zip)

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snRNA-seq_and_spatial_transcriptomics.zip

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