Therapeutic methods in the treatment of triple-negative breast cancer - a review

Ziętara Karolina, Pawlina Mateusz, Widłak Karolina, Orzechowska Aleksandra, Raksa Karolina, Nowakowska Katarzyna, Lewkowicz Martyna, Chromiak Karol. Therapeutic methods in the treatment of triple-negative breast cancer - a review. Journal of Education, Health and Sport. 2022;12(7):784-789. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.07.078

https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.07.078

https://zenodo.org/record/6908093

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

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Received: 16.07.2022. Revised: 17.07.2022. Accepted: 26.07.2022.

Therapeutic methods in the treatment of triple-negative breast cancer - a review

Karolina Ziętara¹, Mateusz Pawlina¹, Karolina Widłak², Aleksandra Orzechowska¹, Karolina Raksa¹, Katarzyna Nowakowska¹, Martyna Lewkowicz¹, Karol Chromiak¹

¹ Student, Faculty of medicine, Medical University of Lublin

² Department of Pneumonology, Oncology and Allergology, Medical University of Lublin

Karolina Ziętara: https://orcid.org/0000-0002-6754-9263, kar.zietara@gmail.com

Mateusz Pawlina: https://orcid.org/0000-0001-7354-4883, mateuszpawlina14@gmail.com

Karolina Widłak: https://orcid.org/0000-0002-4850-5716, karo.widlak@gmail.com

Aleksandra Orzechowska: https://orcid.org/0000-0002-6919-0928, olaorzechowska14@gmail.com

Karolina Raksa: https://orcid.org/0000-0001-5571-1035, karolinaraksa@op.pl

Katarzyna Nowakowska: https://orcid.org/0000-0002-7980-767X, k.nowakowska98@gmail.com

Martyna Lewkowicz: https://orcid.org/0000-0002-2839-2435, lewkowicz0martyna@gmail.com

Karol Chromiak: https://orcid.org/0000-0002-4683-5762, chromiakk@onet.pl

Abstract

Breast cancer is a common female malignancy characterized by the presence of multiple subtypes taking into account, among other things, hormonal activity. The purpose of this study is to show the therapeutic options for triple-negative breast cancer (TNBC). A review of the literature in databases such as PubMed, Google Scholar, and Web of Science by keywords was performed, taking into account papers from 2017-2022. The main therapeutic approaches are surgical intervention and systemic chemotherapy (neoadjuvant and adjuvant). Unsatisfactory results from chemotherapy have prompted researchers to work on other methods to combat TNBC. Clinical trials are being conducted on the use of immunotherapy focusing mainly on molecules against PD-1, PD-L1, and CTLA-4. Targeted therapy is the latest proposed form of therapy, which offers the possibility of introducing a drug in the future that will be tailored to the patient's needs limiting the negative therapeutic impact.

Keywords: breast cancer, triple-negative, treatment, surgery, chemotherapy, immunotherapy, targeted therapy