Long term Th2 cytokines immunotherapy is beneficial for EoE pediatric patients?

Eosinohilic esophagitis (EoE) and gastroesophageal reflux diseases (GERD) are closely
related esophageal disorders, and both accumulate eosinophils in the esophagus. However,
origin of both these diseases are very different. The evidence indicates that acid reflux is the
main cause of GERD; whereas EoE is induced in response to food or environment allergens
exposed accumulation of inflammatory cells like eosinophils, mast cells and T cell subsets. EoE
is a global problem, and effect even 1 year old children to adult population. Currently,
mepolizumab (anti-IL-5) neutralization therapy sdata showed reduced epithelial layer
eosinophilia in EoE,1, 2 and most recently FDA approved FDA has also approved Dupixent (anti-
IL4R and anti-IL-13) for EoE following Phase 3 randomized, double-blind, placebo-controlled
trial. The efficacy and safety of Dupixent 300 mg weekly patients 12 year or older on limited
patient number, 69% and 64% reduction in EoE symptoms from baseline compared to 32% and
41% for placebo (FDA, 2022). In this commentary, we raised few concerns to be considered on
these therapies based on the significance of IL-5, IL-4 in maintaining the innate immunity of the
young children are mostly effected by EoE that require long term immunotherapy of
mepolizumab (anti-IL-5) or Dupixent (anti-IL4R and anti-IL-13).