Published June 24, 2022 | Version v1
Poster Open

Bispyridinium Compound Screening Using Phospholipid Target Sensor Elements

  • 1. University of Leeds
  • 2. Dstl, Porton Down, Salisbury, UK
  • 3. Novamechanics Ltd, Nicosia, Cyprus

Description

Pyridinium is the cationic conjugate acid of pyridine. It is synthesised from the electrophilic attack on the pyridine nitrogen atom [1]. The lone electron pair on the nitrogen atom is not delocalised and hence pyridine can be easily protonated to form the pyridinium ion. Compounds with pyridinium inclusion are known to hydrogen bond to the phosphate moiety of lipid layers such as dimyristoyl phosphatidylcholine (DMPC) bilayers [2]. Bispyridinium (BP) compounds have important applications as potential pharmaceuticals and antidotes to nerve agent poisoning [3-5]. As a result, in order to understand the molecular initiating events in the biological activity of BP compounds, it is essential as a first step to elucidate their interactions with biological membrane models.

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SABYDOMA_Nanoweek2022_PosterUNIVLEEDS-Nelson_Bispyridinium.pdf

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Additional details

Funding

SABYDOMA – Safety BY Design Of nanoMaterials - From Lab Manufacture to Governance and Communication: Progressing Up the TRL Ladder 862296
European Commission