Supplementary scRNA data for manuscript "MicroRNA-223 dampens neutrophil-mediated lung inflammation during pneumococcal pneumonia"

Online supplementary data including the seurat object used in scRNA analysis 

AUTHORS:

Cengiz Goekeri,a,b# Peter Pennitz,a Wibke Groenewald,a Ulrike Behrendt,a Holger Kirsten,c Christian M. Zobel,d Sarah Berger,a Gitta A. Heinz,e Mir-Farzin Mashreghi,e,f Sandra-Maria Wienhold,a Kristina Dietert,g,h Anca Dorhoi,i,j Achim D. Gruber,g Markus Scholz,c Gernot Rohde,k,l,m Norbert Suttorp,a,l,n CAPNETZ Study Group,l Martin Witzenrath,a,l,n and Geraldine Nouaillesa#

a Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany
b Cyprus International University, Faculty of Medicine, Nicosia, Cyprus
c Universität Leipzig, Institute for Medical Informatics, Statistics, and Epidemiology, Leipzig, Germany 
d Bundeswehrkrankenhaus Berlin, Department of Internal Medicine, Berlin, Germany 
e Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), ein Institut der Leibniz-Gemeinschaft, Therapeutic Gene Regulation, Berlin, Germany
f Berlin Institute of Health at Charité – Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany
g Freie Universität Berlin, Institute of Veterinary Pathology, Berlin, Germany
h Freie Universität Berlin, Veterinary Centre for Resistance Research (TZR), Berlin, Germany
i Friedrich-Loeffler-Institut, Institute of Immunology, Greifswald, Germany 
j University of Greifswald, Faculty of Mathematics and Natural Sciences, Greifswald, Germany 
k Goethe-Universität Frankfurt am Main, Department of Respiratory Medicine, Medical Clinic I, Frankfurt/Main, Germany. 
l CAPNETZ STIFTUNG, Hannover, Germany. The members of the CAPNETZ Study Group are stated in the acknowledgements section.
m Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany
n German Center for Lung Research (DZL), Berlin, Germany
 

Running Title:

Regulation of acute lung inflammation by microRNA-223

Support statement:

This research was funded by a German Federal Ministry of Education and Research (BMBF) grant to M. Witzenrath, grant number e:Med CAPSyS (01ZX1304B, 01ZX1604B) and an academic stipend awarded to C. Goekeri by the Interdisciplinary Center of Infection Biology and Immunity (ZIBI). G. Nouailles, SM. Wienhold and M. Witzenrath were supported by the BMBF and by the Agence Nationale de la Recherche (ANR) in the framework of MAPVAP (16GW0247). A.D. Gruber received funding from the DFG (grant number SFB-TR84 Z01b). N. Suttorp received funding from the DFG (grant number SFB-TR84 B01, C09 and Z02) and BMBF (e:Med CAPSyS grants 01ZX1304B and 01ZX1604B). M. Witzenrath received funding from the DFG (SFB-TR84 C06 and C09, SFB1449 B02), the BMBF in the framework of e:Med CAPSyS (01ZX1304B, 01ZX1604B), PROVID (01KI20160A), e:Med SYMPATH (01ZX1906A), NUM-NAPKON (01KX2021, 01KX2121) and the BIH (CM-COVID). H. Kirsten and M. Scholz received funding from the BMBF in the framework of e:Med CAPSyS (01ZX1304B, 01ZX1604B), PROVID (01KI20160A) and e:Med SYMPATH (01ZX1906A). C. Goekeri and P. Pennitz are supported by the Charité 3R.