Published June 16, 2022 | Version v1
Software Open

Automatic Generation of Lumped Parameter Cardiovascular Physiology Model

  • 1. Clemson University


This software will construct and run a realistic closed-loop lumped-parameter model of cardiovascular physiology.  The software automatically tunes the model parameters to achieve a set of desired hemodynamic outputs specified by the user, including:

Systolic aortic pressure, diastolic aortic pressure, heart rate, systolic left ventricular volume, diastolic left ventricular volume, systolic right ventricular volume, diastolic right ventricular volume

The software will set model parameters such that all other hemodynamic outputs not specified by the user will fall within realistic clinical ranges.  

We are currently in the process of making some adjustments in the lumped-parameter circuit.  We will post an updated circuit model and the corresponding tuning algorithm once they are finalized.


Related conference presentations:

Automated Tuning of a Lumped Parameter Model for Simulating Resting Cardiovascular Physiology.

1) Summer Biomechanics, Bioengineering and Biotransport Conference, Cambridge, MD, June 20-23, 2022.

2) 9th World Congress of Biomechanics, Taipei, Taiwan, July 10-14, 2022.


Cardiovascular Modeling & Experimentation Research Laboratory, Clemson University



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CAREER: Hybrid Experimental-Computational Modeling Framework for Transformative Research and Multidisciplinary Education in Cardiovascular Biomechanics 1749017
National Science Foundation