D15.4 - Report on approaches to identify mixture health effects

This report describes the purpose of mixture risk assessment case studies conducted in the context of HBM4EU. It also describes an advanced decision tree and workflow scheme for the hazard assessment arm of mixture risk assessment. The decision tree adopts the principle of advancing mixture risk assessment in a step-wise manner to approximate the scientific principles of experimental mixture assessments based on Dose Addition or Independent Action. We newly introduce the concept of drivers of mixture effects and the exploitation of the Maximum Cumulative Ratio as a tool for elaborating risk assessment options.