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Published May 5, 2022 | Version v1
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Associated data files and scripts for 'Ancestry-inclusive dog genomics challenges popular breed stereotypes'

Creators

  • 1. University of Massachusetts Medical School
  • 2. Broad Institute
  • 3. International Association of Animal Behavior Consultants*
  • 4. Arizona State University
  • 5. Darwin's Ark Foundation*

Description

Behavioral genetics in dogs has focused on modern breeds, isolated subgroups <200 years old with distinctive physical, and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,371 purebred and mixed-breed dogs, and densely genotyping (~45 million markers) a subset of 2,155 dogs. Most behavioral traits are heritable (h2>25%), and admixture patterns in mixed-breed dogs can reveal breed propensities. However, breed poorly predicts an individual purebred dog's behavioral phenotype, explaining just 9% of variation. Using genome-wide association, we identify 11 loci significantly associated with howling and other behaviors, and show characteristic breed behaviors are genetically complex. Behavior-associated loci are not unusually differentiated in modern breeds, but breed propensities do align, albeit weakly, with ancestral function. We propose behaviors now perceived as characteristic of modern breeds likely derive from thousands of years of polygenic adaptation predating breed formation, with modern breeds distinguished primarily by aesthetic, not behavioral, traits.

Notes

Funding provided by: National Cancer Institute
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000054
Award Number: R01CA255319

Funding provided by: National Cancer Institute
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000054
Award Number: R37CA218570

Funding provided by: National Human Genome Research Institute
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000051
Award Number: R01HG008742

Funding provided by: National Institute on Aging
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000049
Award Number: U19AG057377

Funding provided by: National Institute of Mental Health
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000025
Award Number: R21MH109938

Funding provided by: NIH Office of the Director
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000052
Award Number: R24OD018250

Funding provided by: National Cancer Institute
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000054
Award Number: F32CA247088

Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number: EF-2022007

Funding provided by: Broad Institute
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100013114
Award Number: BroadIgnite

Funding provided by: Broad Institute
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100013114
Award Number: Next10

Files

DarwinsArk.zip

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Additional details

Related works

Is derived from
10.5281/zenodo.5808330 (DOI)
Is source of
10.6084/m9.figshare.16608793 (DOI)