Left versus right sided colon cancer: Differences in extracellular matrix composition visualized by non linear optical imaging (NLOM)

Introduction

Location of tumour within the colon is gaining traction as a crucial factor in determining disease progression, prognosis and management. Clinicopathological features, protein / genetic biomarkers, and response to therapy, varies between left (LSCC) and right sided colon cancer (RSCC).^[1] However, differences in tumour microenvironment, particularly the distribution and density of extracellular matrix (ECM) has not been studied. We used 2-photon laser scanning microscopy (2PLSM) to visualise label-free components of ECM, so as to depict specific patterns in LSCC and RCSS for subclassification.

References
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