Friedel-Craft Reaction of α-(+) Acid Halide

Few optically active unsymmetrical aromatic ketones were reported in the literature. With a view of study the effect of different types of alkyl substituents on the optical activity the present study has been undertaken, to prepare' optically active unsymmetrical aromatic ketones of the type

                                    _{\(\begin {matrix} Ar―CO―CH_2―CH―CH_2CH_3 \\ \mid\\ CH_3 & \end{matrix} \)}

 by Friedel-Craft reaction. \(a\)-(+)-2-methyl valeryl chloride was condensed with different types of aromatic hydrocarbons in presence of anhydrous aluminium chloride. The optical rotations of these ketones have been measured and recorded in Table 1.