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Published April 18, 2022 | Version v2.1.0
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raphael-group/decifer: Outlier mutations printed to separate file

  • 1. Princeton University
  • 2. University of Illinois at Urbana-Champaign

Description

For each SNV, DeCiFer selects one of K clusters and the genotype tree that has the highest likelihood. However, even the best-fitting model still produces an expected VAF that is far away from an SNVs observed VAF. For these SNVs, we print the results to a separate output file with suffix _Outliers_output.tsv. How many standard deviations the observed VAF of an SNV needs to be from the expected VAF (computing using the DCF/CCF cluster center) in order to be classified as an outlier and printed to this separate file can be changed using the new --vafdevfilter option, which has a default value of 1.5.

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raphael-group/decifer-v2.1.0.zip

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