raphael-group/decifer: Outlier mutations printed to separate file
- 1. Princeton University
- 2. University of Illinois at Urbana-Champaign
Description
For each SNV, DeCiFer selects one of K clusters and the genotype tree that has the highest likelihood. However, even the best-fitting model still produces an expected VAF that is far away from an SNVs observed VAF. For these SNVs, we print the results to a separate output file with suffix _Outliers_output.tsv
. How many standard deviations the observed VAF of an SNV needs to be from the expected VAF (computing using the DCF/CCF cluster center) in order to be classified as an outlier and printed to this separate file can be changed using the new --vafdevfilter
option, which has a default value of 1.5.
Files
raphael-group/decifer-v2.1.0.zip
Files
(1.5 MB)
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Additional details
Related works
- Is supplement to
- https://github.com/raphael-group/decifer/tree/v2.1.0 (URL)