Published March 31, 2022
| Version v2
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Role of Vitamin D in Pathogenesis, Diagnosis, and Treatment of Inflammatory Diseases
Creators
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Ahadiat, Seyed-Amirabbas
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Ghazalgoo, Arezoo
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Ghasemi Falaverjani, Hajar
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Azizi Hassan Abadi, Saeme
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Bagherianlemraski, Mobina
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Namazifar, Farzaneh
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Pourbagher Benam, Sasan
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Motioleslami, Moein
- Sargazi Moghadam, Nasibeh
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Babashpour, Sevil
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Kazemi, Fatemeh
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Atighi, Ramin
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Mehrpouyan, Afsaneh
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Meftah, Elahe
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Salemi, Mohammad Hossein
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Lotfi, Hamed
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Bitaraf, Ali
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Khosravifar, Mina
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Shafagh, Seyyed-Ghavam
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sharifi, Roya
- Bemana, Reza
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Yadollahifarsani, Sepideh
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Soleimani, Parisa
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Ghafarzadeh, Saghi
- Sajedi Shacker, Mahdi
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Mashatan, Noushin
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Shavakhi, Mitra
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Khodadadiyan, Alireza
- Ahmadian, Shahla
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Shirdel, Elham
- Ghebleh, Aida
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Javanshir, Salar
- Shahi, Shayan
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Ahmadi Beni, Maryam
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Kiani, Moein
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Poursaravani,
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Hematian, Saeid
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Jafari, Delaram
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Taheri, Fatemeh
Description
Vitamin D performs its immunomodulatory effects on T lymphocytes, by inhibiting the synthesis of pro-inflammatory Th1 cytokines (IL-1, IL-2, IL-6, IL-12, IFN-γ, TNF-α, and TNF-β), and triggering the synthesis of anti-inflammatory regulatory Th2 cytokines (IL-4, IL-5, and IL-10).
Therefore, vitamin D potentiates the innate immune system and regulates the adaptive immune system, mainly by triggering the split to Th2 and regulatory T cells (Tregs), over the Th1 and Th17 lymphocytes differentiation, via direct and indirect effects on naive CD4+ cells. The general finding is an evident role of switching capacity, from a pro-inflammatory autoimmune to an anti-inflammatory tolerogenic immunological effect.
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