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Published February 16, 2022 | Version v1
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Extended Data Fig. 5 in Bat coronaviruses related to SARS-CoV-2 and infectious for human cells

Authors/Creators

  • 1. Institut Pasteur, Université de Paris, Pathogen Discovery Laboratory, Paris, France & Institut Pasteur, Université de Paris, The OIE Collaborating Center for the Detection and Identification in Humans of Emerging Animal Pathogens, Paris, France
  • 2. Institut Pasteur du Laos, Vientiane, Lao People's Democratic Republic
  • 3. Institut Pasteur, Université de Paris, CNRS UMR 3569, Structural Virology Unit, Paris, France
  • 4. Institut Pasteur, Université de Paris, CNRS UMR 3569, Molecular Genetics of RNA Viruses Unit, Paris, France
  • 5. Institut Pasteur, Université de Paris, CNRS UMR 3528, Structural Bioinformatics Unit, Paris, France
  • 6. Faculty of Environmental Sciences, National University of Laos, Vientiane, Lao People's Democratic Republi
  • 7. Faculty of Environmental Sciences, National University of Laos, Vientiane, Lao People's Democratic Republic
  • 8. Institut Pasteur, Université de Paris, CNRS UMR 3528, Structural Bioinformatics Unit, Paris, France & Institut Pasteur, Université de Paris, National Reference Center for Respiratory Viruses, Paris, France
  • 9. Institut Pasteur, Université de Paris, Pathogen Discovery Laboratory, Paris, France & Institut Pasteur, Université de Paris, Bioinformatic and Biostatistic Hub - Computational Biology Department, Paris, France
  • 10. Institut Pasteur, Université de Paris, Pathogen Discovery Laboratory, Paris, France & Institut Pasteur, Université de Paris, The OIE Collaborating Center for the Detection and Identification in Humans of Emerging Animal Pathogens, Paris, France & Ecole Nationale Vétérinaire d'Alfort, University of Paris-Est, Maisons-Alfort, France

Description

Extended Data Fig. 5 | Additionalanalysisof the MDsimulationsof the BANAL-52/103 RBD–hACE2 complex. Comparisonof thetimeseriesof interface RMSDduringthecourseof two MDsimulationsof the BANAL-52/103 RBD–hACE2 complexwithshort (BANAL-52/103-CoV.1) andlong (BANAL- 52/103-CoV.1*) equilibrationphase.Thelargefluctuationsof theinterface RMSDareduetotheflexibilityof the RBDloopbetweenresidues S443 and Y449 (insets, inyellow).Whentheseresidueswerenotincludedinthe calculationof theinterface RMSD, thetimeseriesdisplayedamorestable behavior (BANAL-52/103-CoV.1-Land BANAL-52/103-CoV.1*-L).

Notes

Published as part of Temmam, Sarah, Vongphayloth, Khamsing, Baquero, Eduard, Munier, Sandie, Bonomi, Massimiliano, Regnault, Béatrice, Douangboubpha, Bounsavane, Karami, Yasaman, Chrétien, Delphine, Sanamxay, Daosavanh, Xayaphet, Vilakhan, Paphaphanh, Phetphoumin, Lacoste, Vincent, Somlor, Somphavanh, Lakeomany, Khaithong, Phommavanh, Nothasin, Pérot, Philippe, Dehan, Océane, Amara, Faustine, Donati, Flora, Bigot, Thomas, Nilges, Michael, Rey, Félix A., Werf, Sylvie van der, Brey, Paul T. & Eloit, Marc, 2022, Bat coronaviruses related to SARS-CoV-2 and infectious for human cells, pp. 330-336 in Nature 604 on page 16, DOI: 10.1038/s41586-022-04532-4, http://zenodo.org/record/6419063

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Is part of
Journal article: 10.1038/s41586-022-04532-4 (DOI)
Journal article: urn:lsid:plazi.org:pub:FFAAFF911E43D104D6427538FF95065B (LSID)
Journal article: https://zenodo.org/record/6419063 (URL)