Studies in Heterocyclic Compounds, Part II. Synthesis of ethyl (arylsulphonamidobenzeneazo) aceto-and benzoyl-acetates, 1, 3-disubstituted-4-(substituted sulphonamido-benzeneazo) pyrazol-5-ones and evaluation of their antibacterial properties.

Department of Chemistry, University of Delhi, Delhi 110007.

Manuscript received 20 July 1973 , accepted 19 September 1973

Ethyl acetoacetate and ethylbenzoylacetate are coupled with diazotised N¹-2-methoxyphenyl-, N¹ -4-bromophenyl-, N¹ -guanidyl-, N¹ -2,4-dichlorophenyl-and N¹_:3,4-dimethylphenyl sulphanilamides to give ethyl (arylsulphonamidobenzeneazo) aceto-and benzoylacetates. These on reaction with four different carbonyl reagents, furnished 1, 3-disubstituted-4-substituted sulphonamido­benzeneazo) pyrazole-5-ones. All the azo compounds and the pyrazol-5-ones have been screened \(in\) \(vitro\) by the cup-plate agar diffusion method for their antibacterial properties.