Postscript:Ethical, Economic, Managerial and Political Reflections Triggered by New Discovery of Clopidogrel

In the previous article "Prediction on Clopidogrel's Abnormal Behaviors and Pharmacobehavioral Economics", the authors propose to establish new disciplines such as pharmacobehavioral economics. Although the establishment of a new discipline normally brings about a breakthrough in the development of the field, from December 2012 to July 2021, this paper had been rejected by many journals, and the correct results of empirical studies turned into a hot potato. During this process, both invisible hand and visible hand became barriers to the formal publication of this article, justice and morality were ignored,and the market and regulators failed. So far, for clopidogrel whose global cumulative sales have exceeded $90 billion, the treatment guidelines based on the incorrect results of Phase III CAPRIE cannot be corrected, and the global medical economic resources have been excessively consumed for a long time. At present, the global COVID-19 is serious, but some false information has been widely publicized by some media, misleading the public, causing confusion in thinking, harming the epidemic prevention and control, and interfering with economic recovery. However, the rumour-mongering media is difficult to suppress. Therefore, we suggest that new disciplines such as quantitative media ethics etc. should be established to conduct ethical evaluation or hierarchical management of economic and media behaviors from a new perspective, reduce the ability of inferior media to mislead the public, and construct world stability and peace under the new perspective. The author also proposes to establish an eight-level grading standard for media based on publishing false information or rumors.

Based on the prediction function combined with pharmacobehavioral economics or medical-behavioral economics and game theory, within one day 8 years ago, from massive data, we quickly found that there were serious evidence-based medicine data errors and illogical in another drug with abnormal behavior. The author designs a new economic system, which is the new negative feedback mechanism of market economy operation when the market and the government or regulation failed at the same time. The process of disclosing the illogical data and wrong results of the CAPRIE trial, which cannot be officially published so far, shows that absolute neoliberal economics should sometimes be just a skilled method or methodology for high IQ people or interest groups to transfer wealth as much as possible under the banner of freedom economics. In economic activities, "general disequilibrium theory", rather than "general equilibrium theory", widely exists in market economic activities. Therefore, it can be seen that the market economy in which capital participates is usually asymmetric, and asymmetric economics is the mainstream of market economy. In a discipline, the accurate interpretation of terms is crucial for communication of the discipline. It is suggested to replace "invisible hand" with "profit driven hand".

Although pharmacobehavioral economics etc. can be used to predict and reveal issues from abnormal behaviors in the pharmaceutical industry under asymmetry information, it can be more used to describe or predict the relationship between pharmaceutical economic growth and R&D, clinic, prevention and health care behaviors from a positive perspective. What we can predict in the future is that in some major disease treatment areas, there will inevitably be many drugs with annual cumulative sales of more than $50 billion and more than $30 billion within a 10 to 30 year cycle after the drug is put into the market.

Although the change or improvement to behavior in the treatment of diseases may sometimes lead to the decrease or increase in benefits of the pharmaceutical industry itself, they may bring significant improvement to the global economy and more security or health to mankind, such as the change of the definition and treatment behavior of hypertension, and the changes of treatment behavior of malaria and viral cold. The current guidelines on the clinical treatment behaviors of hypertension do not even consider that hypertension can be cured in the design ideas, the definition and standard of hypertension has been wrong for a long time, which also leads to the mistake of the guidelines for the clinical medication of hypertension. The borderline hypertension should be regarded as hypertension and hypertension that should be treated immediately. Perhaps the subversive revision of medical textbooks and the global guidelines on hypertension will be no less efficient than the development of twenty new antihypertensive drugs. It will also help to significantly reduce the mortality of stroke or cardiovascular disease etc, and a huge loss in productivity.

Comparative studies on the medical and health behavioral economics, government behaviors and political ethics of some regions or countries in the current COVID-19 are not merely conducive to rapid epidemic prevention and control, saving lives, improving national governance capacity and level, and effectively promoting regional, national and global economic recovery, but also conducive to promoting the reasonable construction of quantitative administrative ethics and other disciplines and the classification of politicians or statesmen, which is more conducive to cultivate more peace fighters, eliminate the research of biological weapons, reduce the number of conflicts and wars, and promote world peace.