Synthesis of Some New Diarylsulphides and Diarylsulphones Containing Quinazol-4-One Moiety

Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt, A.R.E.

Manuscript received 18 April 1980, revised 28 September 1980, accepted 6 November 1980

4-Amino-4'-nitrodiphenylsulphide and 4-amino-2'-nitrodiphenylsulphide(l) were smoothly condensed with 2-methyl-3, 1-benzoxazin-4-one(ll) to produce the corresponding 2-methyl-3-diphenylsulphidoquinazol-4- ones(lll). 2-Styryl-3-diphenylsulphidoquinazol-4-ones(IV) were prepared by heating(III) with the appropriate aromatic aldehydes using piperidine as a basic catalyst. Compounds(IV) oxidized easily by H₂O₂/gl. acetic acid mixture to produce the corresponding sulphones(V). The biological activities of some of these compounds were tested.