Synthesis and Hypoglycemic Activity of Substituted-3-(substituted-arylcarbiminoacetyl)aminomethyl-4(3H)-quinazolone

Department of Chemistry, Lucknow University, Lucknow-226 007

Manuscript received 31 October 1985, accepted 25 June 1986

Thirtytwo new substituted-3-(substituted-arylcarbitninoacetyl)aminometh31-4(3H)- quinazolone (2) were synthesised by condensation of substituted-3-(4 -aryl substituted­-carbamidoacetyl)aminomethyl-4(3H)-quinazolones (I) and p-substituted-aniline in anhy­drous pyridine. The compounds were screened for hypoglycemic activity Only eleven out of thirtytwo compounds were found to be hypoglycemic. The compounds were characterised by tlc, elemental analyses and ir spectra.