Conductance Behaviour of some associated Hydrochlorides of Medicinal Interest in Aqueous Solution at 298 K

Department of Chemistry, University of Kalyani, Kalyani-741 235

Manuscript received 12 April 1989, revised 19 September 1989, accepted 6 February 1990

The conductance studies of hydrochlorides of well-known druge (like pseudoephedrine, isoxsuprine, metoclopramide, pentazocine, propranalol, dicyclomine and ᴅʟ-phenylpropanolamine) in aqueous solutions have been made. The analysis of the results using Shedlovsky's equation indicates that the compounds are associated in aqueous solutions. Improved values of the association constants Kᴀ and Ʌ_o have been determined using Fuoss equation. The Ʌ_o values of the cations compare very well with those fortetraalkylammonium ions and it is expected that they undergo hydrophobicinteractions in aqueous solutions.