Synthesis of some New Thienopyrimidines containing 4-Thiazolidinone Moiety

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
Manuscript received 18 February 1988, accepted 8 July 1988

The reaction of 4-mercaptopyrimidines (1) with halogenated active methylene in aqueous sodium carbonate gave compounds 2. Compound 2c, g were allowed to react with hydrazine hydrate in ethanolts give the acid hydrazides (4a, b). The latter were condensed with aromatic aldehydes and ketones to give the corresponding hydrazones (5). Cyclocondensation of thioglycolic acid on the hydrazones (5) gave the thiazoli-dinothienopyrimidines (6).