Safety and efficacy of cenobamate in patients with uncontrolled focal seizures - a review of the literature

Pietrzak Zofia, Stefaniak Martyna, Dzikowski Piotr, Nowicka Emilia, Obel Michał, Piecewicz-Szczęsna Halina. Safety and efficacy of cenobamate in patients with uncontrolled focal seizures - a review of the literature. Journal of Education, Health and Sport. 2022;12(2):48-55. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.02.005

https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.02.005

https://zenodo.org/record/5961654

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2022;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 26.01.2022. Revised: 26.01.2022. Accepted: 03.02.2022.

Safety and efficacy of cenobamate in patients with uncontrolled focal seizures - a review of the literature

Zofia Pietrzak¹, zofer.pietrzak@gmail.com; 

https://orcid.org/0000-0001-8469-6225

Martyna Stefaniak¹, martynastefaniakk@gmail.com; 

https://orcid.org/0000-0002-8036-8379

Piotr Dzikowski¹, piotrekdzikowski22@gmail.com;

https://orcid.org/0000-0002-6335-9171

Emilia Nowicka¹, e.nowicka22@gmail.com;

https://orcid.org/0000-0002-2743-1551

Michał Obel¹, michalobel3@gmail.com;

https://orcid.org/0000-0003-1237-8732

Halina Piecewicz-Szczęsna², halpiec@gmail.com;

https://orcid.org/0000-0002-0573-7226

1. Students’ Scientific Association at the Chair and Department of Epidemiology, Medical University of Lublin, ul. Radziwiłłowska 11 (Collegium Medicum), 20-080 Lublin, Poland

2. Chair and Department of Epidemiology, Medical University of Lublin,
ul. Radziwiłłowska 11 (Collegium Medicum), 20-080 Lublin, Poland

Abstract

Epilepsy is one of the most common diseases of the nervous system, characterized by the occurrence of recurrent and unprovoked seizures, which are an expression of abnormal brain activity associated with sudden and excessive bioelectric discharges. Partial seizures come from specific areas of the brain. They can run with motor, autonomic, sensory, and psychological symptoms. Currently, new active substances are sought that can be used in the treatment of drug-resistant partial seizures.

The aim of the study is to evaluate the safety and efficacy of cenobamate in the treatment of patients with uncontrolled, partial seizures. Our study material consisted of publications, which were found in PubMed, Google Scholar, and Embase databases. In order to find the proper publications, the search has been conducted with the use of a combination of keywords like: “cenobamate”, “focal seizures”, “cenobamate in epilepsy”. The first step was to find proper publications from the last 10 years. The second step was to carry out an overview of the found publications.

Studies have shown that treatment with cenobamate significantly improved seizure control in adults with uncontrolled focal seizures. Long-term use of cenobamate is safe and well-tolerated by patients. Most adverse events are mild or moderate.

Key words: cenobamate; focal seizures; epilepsy; epilepsy treatment;