Published January 27, 2022 | Version v1
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Dataset related to the article "CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry"

  • 1. University Cardiology Unit, Policlinic University Hospital, Bari, Italy
  • 2. Cardiovascular Imaging Department, King's College London, London, UK.
  • 3. Centro Cardiologico Monzino IRCCS
  • 4. Institute of Management, Scuola Superiore Sant'Anna, Pisa, Italy
  • 5. Scienze Radiologiche, Department of Medicine and Surgery, University of Parma, Parma, Italy
  • 6. Cardiovascular Department, CMR Center, University Hospital Lausanne, CHUV, Switzerland.
  • 7. U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa
  • 8. Loyola University of Chicago, Chicago, IL, USA
  • 9. Department of Cardiology, Città della salute e della Scienza - Ospedale Molinette -Turin, Pavia, Italy
  • 10. Department of Radiology, Fondazione IRCCS Policlinico S.Matteo, Pavia, Italy
  • 11. Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
  • 12. Department of Radiology, University Hospital Leuven, Leuven, Belgium.
  • 13. Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
  • 14. Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
  • 15. Cardiology Department, Policlinico Casilino, Rome, Italy
  • 16. Cardiology Department, Policlinico Casilino, Rome, Italy.
  • 17. Department of Cardiology, ASST Monza, P.O. Desio, Italy.
  • 18. Department of Cardiology, Policlinico di Monza, Monza, Italy.
  • 19. Department of Radiology, University of Foggia, Foggia, Italy
  • 20. Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Medical School, Padova, Italy.
  • 21. Cardiology Department, Ca' Foncello Hospital Azienda N 2 Marca Trevigiana, Treviso, Italy.
  • 22. Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
  • 23. Department of Cardiology, Infermi Hospital, Rimini, Italy
  • 24. Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
  • 25. Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
  • 26. Maria Cecilia Hospital, GVM Care & Research, Cotignola (RA), Italy.
  • 27. Scienze Radiologiche, Department of Medicine and Surgery, University of Parma, Parma, Italy.
  • 28. Department of Cardiology, Azienda Ospedaliero-Universitaria, Parma, Italy.
  • 29. Cardiac Department, Vannini Hospital Rome, Rome, Italy.
  • 30. Radiology Department, Vannini Hospital Rome, Rome, Italy.
  • 31. 'De Gasperis' Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • 32. Cardiovascular and Thoracic Department of Careggi Hospital, Florence, Italy
  • 33. Department of Radiology, Careggi Hospital, Florence, Italy.
  • 34. Department of Neuroscience, Imaging and Clinical Sciences, SS Annunziata Hospital, Chieti, Italy

Description

This record contains raw data related to the article “CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry” 
 

Abstract

Aims: The aim of this registry was to evaluate the additional prognostic value of a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in a large cohort of consecutive unselected non-ischaemic cardiomyopathy (NICM) patients.

Methods and results: In the DERIVATE registry (www.clinicaltrials.gov/registration: RCT#NCT03352648), 1000 (derivation cohort) and 508 (validation cohort) NICM patients with chronic heart failure (HF) and left ventricular ejection fraction <50% were included. All-cause mortality and major adverse arrhythmic cardiac events (MAACE) were the primary and secondary endpoints, respectively. During a median follow-up of 959 days, all-cause mortality and MAACE occurred in 72 (7%) and 93 (9%) patients, respectively. Age and >3 segments with midwall fibrosis on late gadolinium enhancement (LGE) were the only independent predictors of all-cause mortality (HR: 1.036, 95% CI: 1.0117-1.056, P < 0.001 and HR: 2.077, 95% CI: 1.211-3.562, P = 0.008, respectively). For MAACE, the independent predictors were male gender, left ventricular end-diastolic volume index by CMR (CMR-LVEDVi), and >3 segments with midwall fibrosis on LGE (HR: 2.131, 95% CI: 1.231-3.690, P = 0.007; HR: 3.161, 95% CI: 1.750-5.709, P < 0.001; and HR: 1.693, 95% CI: 1.084-2.644, P = 0.021, respectively). A composite clinical and CMR-based risk score provided a net reclassification improvement of 63.7% (P < 0.001) for MAACE occurrence when added to the model based on SOC evaluation. These findings were confirmed in the validation cohort.

Conclusion: In a large multicentre, multivendor cohort registry reflecting daily clinical practice in NICM work-up, a composite clinical and CMR-based risk score provides incremental prognostic value beyond SOC evaluation, which may have impact on the indication of implantable cardioverter-defibrillator implantation.

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Is supplement to
Journal article: 10.1093/europace/euaa401 (DOI)