Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients
Creators
- 1. Institute for Oncology and Radiology of Serbia, 11000 Belgrade, Serbia
- 2. Institute for Oncology and Radiology of Serbia, 11000 Belgrade, Serbia; davorr@ncrc.ac.rs (D.R.)
- 3. Institute for Oncology and Radiology of Serbia, 11000 Belgrade, Serbia;
- 4. Institute for Oncology and Radiology of Serbia, 11000 Belgrade, Serbia; vladimir.nikolic@ncrc.ac.rs
- 5. Institute for Oncology and Radiology of Serbia, 11000 Belgrade, Serbia; nemanja.s.stanic@gmail.com
- 6. Institute for Oncology and Radiology of Serbia, 11000 Belgrade, Serbia; jelena.spasic@ncrc.ac.rs
- 7. Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia; tcacev@irb.hr
- 8. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Gastroenterology Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, 08007 Barcelona, Spain; SBEL@clinic.cat
- 9. Institute for Oncology and Radiology of Serbia, 11000 Belgrade, Serbia; milena.cavic@ncrc.ac.rs
- 10. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, 11000 Belgrade, Serbia; goran.jankovic@kcs.ac.rs
Description
Abstract: Background and objectives: This study aimed to evaluate prognostic factors for postrecurrence survival in local and locally advanced colorectal cancer patients. Materials and Methods: A total of 273 patients with stage III and high-risk stage II colorectal cancer were prospectively enrolled. All patients underwent operative treatment of the primary tumor and adjuvant fluorouracil-based chemotherapy. Results: Over the three-year period (2008–2010), a cohort of 273 patients with stage III and high-risk stage II colorectal cancer had been screened. During follow up, 105 (38.5%) patients had disease recurrence. Survival rates 1-, 3- and 5-year after recurrence were 53.9, 18.2 and 6.5%, respectively, and the median post-recurrence survival time was 13 months. Survival analysis showed that age at diagnosis (p < 0.01), gender (p < 0.05), elevated postoperative Ca19-9 (p < 0.01), tumor histology (adenocarcinoma vs. mucinous vs. signet ring tumors, p < 0.01) and tumor stage (II vs. III, p < 0.05) had a significant influence on post-recurrence survival. Recurrence interval and metastatic site were not related to survival following recurrence. Multivariate analysis showed that older age (HR 2.43), mucinous tumors (HR 1.51) and tumors expressing Ca19-9 at baseline (HR 3.51) were independently associated with survival following recurrence. Conclusions: Baseline patient and tumor characteristics largely predicted patient outcomes after disease recurrence. Recurrence intervals in local and locally advanced colorectal cancer were not found to be prognostic factors for post-recurrence survival. Older age, male gender, stage III and mucinous histology were poor prognostic factors after the disease had recurred. Stage II patients had remarkable post-recurrence survival compared to stage III patients.
Notes
Files
Prognostic factors for post-recurrence survival in stage ii and iii colorectal carcinoma patients. medicina-57-01108.pdf
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Additional details
Identifiers
- pmcid
- PMC8538010