Synthesis and Antifungal Activity of some Substituted 1,3,4-Thiadiazolo[3,2-a]-s-triazin-5-phenyl-7-thiones and Imidazo-[2, 1-b ]-1,3,4-thiadiazol-5-ones

Department of Chemistry. University of Jammu, Jammu-180 004

Manuscript received 25 October !994. revised 4 July 1995, accepted 4 August 1995

2-Amino-5-aryl-substituted-1,3,4-thiadiazoles (1) have been refluxed with benzoyllsothiocyanate to get N-[5-aryl-substituted-1,3,4- thiadiazol-2-yl)-N-benzoyl thlonreas (1a). These on refluxing with PCI₅ and POCI₃ give 2-aryl-substituted-1,3,4-thiadiazolo[3,2-a]-s- triazin-5-phenyl-7-thiones (3). Compound 1 on refluxing with chloroacetic acid and anhydrous sodium acetate gives 2-substituted-arylimidazo[2,1-b ]-1,3,4-thiadiazoi-5-ones (2). The compounds have been screened for antifungal activities.